Isolation, biology and chemistry of the disorazoles: new anti-cancer macrodiolides.

Molecular Identification, Isolation and Evaluation of Persian Gulf Actinomycetes as Candidates of Cytotoxic Metabolites Against Breast Cancer

Introduction: Marine actinomycetes have a great potential to produce unique bioactive compounds due to their special adaptation in the harsh ocean environment. The current study aimed to isolate anti-cancer compounds producing actinomycetes from sediments of Harra forests of the Persian Gulf and investigate their potential as anti-breast cancer metabolites. Methods: In the current study, 40 se...

A New Paradigm in Biology – The Effect of Localization of a Protein on its Anti-genicity

Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1

BACKGROUND Disorazoles are polyene macrodiolides isolated from a myxobacterium fermentation broth. Disorazole C1 was newly synthesized and found to depolymerize microtubules and cause mitotic arrest. Here we examined the cellular responses to disorazole C1 in both non-cancer and cancer cells and compared our results to vinblastine and taxol. RESULTS In non-cancer cells, disorazole C1 induced ...

Molecular Identification, Isolation and Evaluation of Persian Gulf Actinomycetes as Candidates of Cytotoxic Metabolites Against Breast Cancer

Introduction: Marine actinomycetes have a great potential to produce unique bioactive compounds due to their special adaptation in the harsh ocean environment. The current study aimed to isolate anti-cancer compounds producing actinomycetes from sediments of Harra forests of the Persian Gulf and investigate their potential as anti-breast cancer metabolites. Methods: In the current study, 40 se...

Anti-cancer and anti-bacterial effects of crude venom of Pseudocerastes persicus snake

Introduction: Antibiotic resistance has been reported as one of the world's most critical public health problems. Recent investigations have demonstrated that venom of some species of snakes have antimicrobial and anticancer activities. In this study, we investigated the antibacterial and anticancer effects of Persian horned viper venom. Antibacterial activity was examined on Escherichia coli,...